化学名（洋名）は？
化学名（洋名）は？
Sacituzumab Govitecan is an antibody-drug-conjugate (molecular weight: ca.159,000) consisting of Govitecan((3RS)-1-[(trans-4-{[(1-{(34S)-38-amino-34-[(4-{[({[(4S)-4,11-diethyl-9-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-4-yl]oxy}carbonyl)oxy]methyl}phenyl)carbamoyl]-28,32-dioxo-3,6,9,12,15,18,21,24,30-nonaoxa-27,33-diazaoctatriacontan-1-yl}-1H-1,2,3-triazol-4-yl)methyl]carbamoyl}cyclohexyl)methyl]-2,5-dioxopyrrolidin-3-yl group (C73H98N11O22; molecular weight:1,481.62)), which is composed of camptothecin derivative and linker, attached to an average of eight cysteine residuesof a recombinant monoclonal antibody. The antibody moiety is an anti-cell surface glycoprotein Trop-2 monoclonal antibody, the complementarity-determining regions of which are derived from mouse antibody and other regions are derived from human IgG1 and produced in mouse myeloma (SpESFX-10) cells. The protein moiety is a glycoprotein (molecular weight: ca.148,000) composed of 2 H-chains (γ1-chains) consisting of 451 amino acid residues each and 2 L-chains (κ-chains) consisting of 214 amino acid residues each.
出典：申請資料概要1.9.1 国内の一般的名称（JAN）
出典：申請資料概要1.9.1 国内の一般的名称（JAN）
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